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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
Fatal fungal infections may be able to resist newer antifungal drugs. Globally, fungal infections are often fatal due to the lack of access to multiple antifungals, which may be required to be utilized in combination. Single antifungals may not be enough to stop a fungal infection from causing the death of a patient.
People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.