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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
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Signs and symptoms of a drug overdose include losing consciousness, fever or sweating, breathing problems, abnormal pulse, and changes in skin color.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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Cucumber slices relieve headaches by tightening blood vessels, reducing blood flow to the area, and relieving pressure.