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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.
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People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.
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Side effects from substance abuse include nausea, dehydration, reduced productivitiy, and dependence. Though these effects usually worsen over time, the constant need for the substance often overcomes rational thinking.
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The FDA recognizes 118 routes of administration.
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In 1864, the first barbiturate (barbituric acid) was synthesized.