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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
The familiar sounds of your heart are made by the heart's valves as they open and close.
Thyroid conditions cause a higher risk of fibromyalgia and chronic fatigue syndrome.
Women are 50% to 75% more likely than men to experience an adverse drug reaction.