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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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Drug-induced pharmacodynamic effects manifested in older adults include drug-induced renal toxicity, which can be a major factor when these adults are experiencing other kidney problems.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The calories found in one piece of cherry cheesecake could light a 60-watt light bulb for 1.5 hours.
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Vaccines prevent between 2.5 and 4 million deaths every year.