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Coca-Cola originally used coca leaves and caffeine from the African kola nut. It was advertised as a therapeutic agent and "pickerupper." Eventually, its formulation was changed, and the coca leaves were removed because of the effects of regulation on cocaine-related products.
About 3.2 billion people, nearly half the world population, are at risk for malaria. In 2015, there are about 214 million malaria cases and an estimated 438,000 malaria deaths.
Medication errors are three times higher among children and infants than with adults.
In the United States, an estimated 50 million unnecessary antibiotics are prescribed for viral respiratory infections.
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.