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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.
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Eat fiber! A diet high in fiber can help lower cholesterol levels by as much as 10%.