A 7-month-old female presents with jaundice, clay-colored stool, ...

[Kthamas]

A 7-month-old female presents with jaundice, clay-colored stool, and an enlarged liver. Testing reveals the absence of intrahepatic bile ducts. This condition is referred to as _____ atresia.
 
  a. hepatic
  b. portal
  c. sinusoidal
  d. biliary

Question 2

An 8-week-old male was recently diagnosed with cystic fibrosis (CF). Which of the following digestive alterations would be expected?
 
  a. Insufficient bile production
  b. Gastric atrophy
  c. Hypersecretion of stomach acid
  d. Nutrient malabsorption

[JYan]

Answer to Question 1

ANS: D
Biliary atresia (BA) is a rare congenital malformation (1 in 8000 to 1 in 18,000 live births) char-acterized by the absence or obstruction of intrahepatic or extrahepatic bile ducts. Jaundice is the primary clinical manifestation of biliary atresia, along with hepatomegaly and acholic (clay-colored) stools. The presenting symptomatology does not support any of the other options.

Answer to Question 2

ANS: D
Approximately 85 of those with CF present early in life with pancreatic insufficiency (PI). PI is the cause of nutrient malabsorption and failure to thrive in children with CF. Infants with CF have normal bile production; they experience pancreatic enzyme deficiency. Diagnosed infants do not experience gastric atrophy or hypersecretion of stomach acid.