Author Question: A physician is attempting a differential diagnosis of a 30-year-old female who is suspected of ... (Read 18 times)

codyclark · **on:** Jun 25, 2018

A physician is attempting a differential diagnosis of a 30-year-old female who is suspected of having systemic lupus erythematosus (SLE).

Which of the following aspects of the physician's assessment and the client's history would be considered potentially indicative of SLE? Select all that apply.
A)
The client has a butterfly rash on her nose and cheeks.
B)
She complains of intermittent joint pain.
C)
The woman states that she has numerous environmental allergies.
D)
The client has been hospitalized twice in the past for pleural effusions.
E)
Blood work indicates low red cells, white cells, and platelets.

Question 2

A nurse is teaching a client about the role that skin plays in forming a barrier to environmental agents and microorganisms.

The nurse would recognize that which of the following types of cells/junctions are involved in the communication and regulation of the immune response and the secretions of cytokines?
A)
Gap junctions
B)
Desmosomes
C)
Adherens junctions
D)
Keratinocytes

Galvarado142 · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

Ans:
A, B, D, E

Feedback:

A butterfly rash, joint pain, pleural effusion, and low levels of blood cellular components are all associated with SLE. Environmental allergies are not noted to be risk factors or associated symptoms of the disease.

Answer to Question 2

Ans:
D

Feedback:

Keratinocytes are now known to be active secretory cells that play an important role in the immunobiology of the skin by communicating and regulating cells of the immune response and secreting cytokines and inflammatory mediators. Gap junctions allow ions and molecules to pass between skin cells, and adherens junctions provide a mechanical connection between cells. Desmosomes are localized patches or plaques that hold two cells tightly together by proteins called cadherins. They are terminal end points on the cell walls of keratinocytes.