A 12-year-old boy has contracted a bacterial infection at school, ...

[nenivikky]

A 12-year-old boy has contracted a bacterial infection at school, and his body has responded by increasing leukocyte production. Place the following components of white blood cell production in the correct chronological order. Use all the options.
 
  A) Myeloblast
  B) Promyelocyte
  C) Myeloid stem cell
  D) Metamyelocyte
  E) Neutrophil

Question 2

A 62-year-old female with a diagnosis of acute and chronic renal failure secondary to diabetes mellitus is receiving her weekly injection of epoetin, a supplementary form of erythropoietin.
 
  Which of the following statements best captures the necessity of this medication?
  A)
  Erythropoietin is needed in order for stem cells to proliferate into committed erythroid precursors.
  B)
  Erythropoietin is necessary for the accurate sensation of hypoxia that stimulates erythropoiesis.
  C)
  Erythropoietin causes the erythrocyte colony-forming units to proliferate and mature.
  D)
  Erythropoietin facilitates the extrusion of the reticulocyte nucleus and the formation of true erythrocytes.

[ktidd]

Answer to Question 1

Ans:
C, A, B, D, E

Feedback:

Granulocytes like neutrophils derive from the myeloid stem cells. The immature precursor cells for each of the cell lines are called blast cells. Myeloblasts, which are the granulocytic precursor cells, have round to oval nuclei, with delicate chromatin and a blue to gray cytoplasm. During the next stage of development, the myeloblasts are transformed into promyelocytes with similar nuclei, but with a cytoplasm containing many primary granules. In the subsequent metamyelocyte stage, the nuclei distort and become arclike, producing the band developmental stage. Metamyelocytes mature into neutrophils.

Answer to Question 2

Ans:
C

Feedback:

Erythropoietin acts primarily in later stages of erythropoiesis to induce the erythrocyte colony-forming units to proliferate and mature through the normoblast stage into reticulocytes and mature erythrocytes. It does not act directly on the stem cells, nor does it play a role in the sensation of hypoxia. Reticulocytes already lack a cell nucleus.

[nenivikky]

TYSM

[pangili4]

Excellent