Two health care workers are comparing the etiology and incidence ...

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Two health care workers are comparing the etiology and incidence of multifactorial inheritance disorders and single-gene disorders. Which of the following statements best captures the relationship between the two types of genetic disorders?
 
  A)
  Multifactorial disorders and single-gene disorders can both be predicted quite accurately.
  B)
  Multifactorial disorders are more likely to involve multiple organs.
  C)
  Multifactorial disorders manifest themselves at birth.
  D)
  A couple with a child with a multifactorial disorder has a higher risk of having another with the same disorder.

Question 2

A 6-year-old boy who has mental retardation secondary to fragile X syndrome has been admitted to hospital with a mitral valve prolapse.
 
  A health care worker who is providing care for the family should have which of the following statements as part of her knowledge base around the disease?
  A)
  The common pattern of inheritance is an affected mother who carries one normal and one mutant allele.
  B)
  The boy's mother had a 100 chance of transmitting the defective gene to her son.
  C)
  Genes of the boy's Y chromosome can be affected in addition to the X chromosome.
  D)
  The boy will pass the gene to all his future daughters who will become carriers.

[Jordin Calloway]

Answer to Question 1

Ans:
D

Feedback:

Parents of a child with a multifactorial disorder have a higher chance of having the disorder recur with another child. Multifactorial disorders are less predictable than single-gene disorders and usually involve single organs. They can manifest themselves at any point in the life span.

Answer to Question 2

Ans:
D

Feedback:

When the affected son procreates, he transmits the defective gene to all of his daughters, who become carriers of the mutant gene. The most common pattern of inheritance for fragile X syndrome is an unaffected mother carrying one normal and one mutant allele. The Y chromosome is not affected.

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