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Author Question: What is used to activate protein C in the chromogenic assay used to determine its concentration? ... (Read 22 times)

ericka1

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on: Jun 25, 2018
What is used to activate protein C in the chromogenic assay used to determine its concentration?
 
  a. Partial thromboplastin
  b. A specific snake venom
  c. Kaolin
  d. Heparin

Question 2

A 37-year-old female patient has a PTT of 76 seconds (reference range, 25 to 37 seconds). Her plasma is mixed 1:1 with normal plasma. An immediate PTT performed on the mix is 74 seconds. Which of the following is the most likely diagnosis?
 
  a. Hemophilia A
  b. Factor VIII inhibitor
  c. Intrinsic factor deficiency
  d. Lupus anticoagulant


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bubulittle310@msn.cn

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Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: B
A specific snake venom is used to activate protein C in its chromogenic assay.

Answer to Question 2

ANS: D
A prolonged PTT that remains prolonged after an immediate repeat of the PTT on the 1:1 mix is seen in patients (either male or female subject) with the lupus anticoagulant. A patient with hemophilia A would most likely be a male subject (female hemophilia A is rare). In addition, the immediate 1:1 mix should correct, as it also would with an intrinsic factor deficiency. The PTT on an immediate 1:1 mix in the presence of a factor VIII inhibitor would also essentially correct.


ericka1

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Reply 2 on: Jun 25, 2018
Excellent

atrochim

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Reply 3 on: Yesterday
Great answer, keep it coming :)

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