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Author Question: A patient has a hematologic malignancy. Karyotyping is performed for all of the following reasons ... (Read 74 times)

Yolanda

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on: Jun 25, 2018
A patient has a hematologic malignancy. Karyotyping is performed for all of the following reasons except:
 
  a. To provide unique cytogenetic profile to confirm the patient's identification
  b. To provide diagnostic information
  c. To identify whether the patient will respond to appropriate therapy
  d. To provide prognostic information

Question 2

Cytogenetics is performed on the bone marrow of a patient, and 20 cells are examined. The patient's karyotype is reported as 47, XX, +7(14), indicating that:
 
  a. This is a female patient with trisomy chromosome 7 found in 14 of the cells examined.
  b. This is a female patient with monosomy chromosome 7 found in 1 of 4 cells examined.
  c. This is a male patient with trisomy 7 found in 1 of 4 cells examined.
  d. This is a male patient with monosomy 7 found in 14 of the cells examined.


prumorgan

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Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: A
Patients with various forms of cancers, including hematologic forms, may exhibit a nonrandom abnormal karyotype. This karyotype can provide useful diagnostic information, identify whether the patient will respond to appropriate therapy, and provide prognostic information for the patient. It does not confirm the patient's identification.

Answer to Question 2

ANS: A
This is a female patient (XX). She has an additional chromosome 7 (+7) found in 14 of the 20 cells that were examined.


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