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Author Question: A patient has two bands on alkaline hemoglobin electrophoresis. One lines up with Hb A and the other ... (Read 156 times)

fasfsadfdsfa

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on: Jun 25, 2018
A patient has two bands on alkaline hemoglobin electrophoresis. One lines up with Hb A and the other is in the S position. Select the best course of action.
 
  a. Report as normal
  b. Report as sickle trait
  c. Report as sickle disease
  d. Confirm sickle gene with tube solubility test

Question 2

All of the following improve the clinical outcome of sickle cell anemia (Hb SS) except which of the following
 
  a. Aggressive prevention and treatment of infection
  b. Presence of Hb F
  c. Transfusions during crises
  d. Keeping the oxygen saturation low


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iman

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Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: D
Other abnormal hemoglobins migrate with Hb S on alkaline hemoglobin electrophoresis; Hb D is an example. However, these hemoglobins are not sickling hemoglobins. Therefore a positive tube solubility test would confirm that the hemoglobin in the S position is Hb S.

Answer to Question 2

ANS: D
Hb S forms insoluble polymers when the oxygen saturation is low. Thus this would precipitate sickling, not improve the outcome of sickle cell anemia. All the other therapies mentioned have been shown to be clinically helpful.


fasfsadfdsfa

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Reply 2 on: Jun 25, 2018
Great answer, keep it coming :)

dantucker

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Reply 3 on: Yesterday
Thanks for the timely response, appreciate it

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