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Author Question: What destroys the red cells in paroxysmal nocturnal hemoglobinuria? a. Macrophages in the bone ... (Read 58 times)

dbose

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on: Jun 25, 2018
What destroys the red cells in paroxysmal nocturnal hemoglobinuria?
 
  a. Macrophages in the bone marrow
  b. Antibodies against red cell membrane antigens
  c. Increased susceptibility to complement
  d. Macrophages in the spleen

Question 2

Which of the following is a typical finding in paroxysmal nocturnal hemoglobinuria?
 
  a. Hemosiderin in urine sediment
  b. Normal levels of decay accelerating factor (CD55)
  c. Hemolysis when blood is alkaline
  d. Elevated white cells and platelets


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JaynaD87

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Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: C
Red cells in paroxysmal nocturnal hemoglobinuria are abnormally sensitive to complement, which is activated on their surface and results in premature destruction of the red cells.

Answer to Question 2

ANS: A
Hemosiderin is present and a useful diagnostic tool in paroxysmal nocturnal hemoglobinuria. Levels of CD55 are decreased in paroxysmal nocturnal hemoglobinuria. Hemolysis occurs when blood is acidic, and platelets and white cells are usually decreased so that the patient is pancytopenic.


dbose

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Reply 2 on: Jun 25, 2018
Thanks for the timely response, appreciate it

laurnthompson

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Reply 3 on: Yesterday
YES! Correct, THANKS for helping me on my review

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