What are the bone marrow findings in hemolytic anemia? a. ...

[madam-professor]

What are the bone marrow findings in hemolytic anemia?
 
  a. Myeloid-to-erythroid (M:E) ratio of 1:1
  b. M:E ratio of 5:1
  c. Reduced cellularity and increased fat
  d. Erythroid hypoplasia

Question 2

The presence of schistocytes in the peripheral blood indicates which of the following processes?
 
  a. Iron deficiency anemia
  b. Intravascular hemolysis
  c. Megaloblastic anemia
  d. Extravascular hemolysis

[cloudre37]

Answer to Question 1

ANS: A
Erythropoiesis is increased (erythroid hyperplasia) in the bone marrow in hemolytic anemia, with no change in the production of granulocytes. The M:E ratio will therefore be decreased (i.e., more erythroid precursors relative to myeloid). Overall cellularity of the bone marrow is increased so that less fat exists.

Answer to Question 2

ANS: B
Schistocytes are fragmented red cells that result when the red cell membrane is damaged by trauma as can be seen in some intravascular hemolytic anemias.