Diepoxybutane causes chromosomal breakage in which of the ...

[crobinson2013]

Diepoxybutane causes chromosomal breakage in which of the following disorders?
 
  a. Acquired aplastic anemia
  b. Fanconi anemia
  c. Diamond-Blackfan anemia
  d. CDA

Question 2

The cause of acquired idiopathic aplastic anemia is:
 
  a. Epstein-Barr virus
  b. Chemicals such as benzene
  c. Radiation
  d. Unknown

[cdmart10]

Answer to Question 1

ANS: B
Diepoxybutane is a deoxyribonucleic acid (DNA) cross-linking agent. When this is added to Fanconi anemia cells in culture, a characteristic chromosomal breakage occurs. This is the diagnostic test for Fanconi anemia.

Answer to Question 2

ANS: D
The term idiopathic means unknown; therefore the cause of idiopathic aplastic anemia is unknown. All the other items listed are possible causes of secondary aplastic anemia.