Correct identification of inclusions in RBCs, when present, ...

[nmorano1]

Correct identification of inclusions in RBCs, when present, provides useful clinical information. They often help suggest the possible cause of an anemia, and thus further appropriate testing.
 
  The first list provides some red cell inclusions. The second list provides choices for composition.
 
  a. Ferric nonheme iron
  b. Deoxyribonucleic acid (DNA)
  c. Precipitated ribonucleic acid (RNA)
  d. Denatured hemoglobin
 
  1. Basophilic stippling
  2. Pappenheimer body
  3. Heinz body
  4. Howell-Jolly body
 
  Match the letter of the correct composition for the inclusion with the number for the inclusion.

Question 2

An appropriately increased RPI greater than 3 is associated with:
 
  a. Iron deficiency anemia
  b. Macrocytic megaloblastic anemia
  c. Hemolytic anemia
  d. Sideroblastic anemia

[snackralk]

Answer to Question 1

1. ANS: C
2. ANS: A
3. ANS: D
4. ANS: B

Answer to Question 2

ANS: C
Only hemolytic anemias have an appropriately increased RPI. The anemia develops not because production is defective but because survival in circulation is significantly shortened. In iron deficiency anemia, insufficient erythropoiesis occurs. In macrocytic megaloblastic and sideroblastic anemias, erythropoiesis is ineffective.