Why are erythrocyte cellular inclusions such as Howell-Jolly ...

[hbsimmons88]

Why are erythrocyte cellular inclusions such as Howell-Jolly bodies found after surgical removal of the spleen?
 
  a. Blood loss from surgery increases erythrocyte production.
  b. Necessary hematopoiesis growth factors produced in the spleen are lost.
  c. Removal of the spleen induces the formation of inclusions.
  d. The absent spleen cannot pit or remove the normally formed inclusions.

Question 2

Where are developing red cells located in the bone marrow?
 
  a. Adjacent to the outer surfaces of the vascular sinuses
  b. Outside the vascular walls of the sinusoids
  c. Deep in the cords
  d. Randomly spaced throughout the cords

[KKcool]

Answer to Question 1

ANS: D
Macrophages in the spleen normally remove abnormal inclusions from red cells, which includes Howell-Jolly bodies. This process is called pitting.

Answer to Question 2

ANS: A
Maturing red cells are found in two places in the bone marrow: (1) adjacent to the outer surfaces of the vascular sinuses and (2) surrounding iron-laden macrophages.

[hbsimmons88]

Thanks for the timely response, appreciate it

[frankwu0507]

TYSM