A 3-year-old girl is confirmed to have ALL by immunophenotyping. She is positive for the CALLA antigen. Cytogenetic analysis results indicate the presence of the Philadelphia chromosome. Which of the following applies to her?
a. A poor prognosis
b. A good prognosis
c. An atypical presentation
d. A tyrosine kinase inhibitor response.
Question 2
A 60-year-old patient was admitted to the local hospital presenting with petechiae on his upper torso. Physical examination revealed a thin, pale man.
Admission labs came back, and the results revealed the presence of 50 blasts and 25 hypergranular promyelocytes. A bone marrow aspirate was ordered that confirmed the peripheral blood picture. Cytogenetic analysis revealed the following: t (11; 17) (q23; q21). How does this impact the patient's care?
a. The patient has a poorer prognosis because of the chromosomal aberration.
b. The patient has a favorable prognosis because of the chromosomal aberration.
c. The patient will be responsive to all-trans retinoic acid.
d. The patient will be resistant to all-trans retinoic acid, so another treatment will be needed.
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