Define the phases and purposes of chemotherapy for ALL. What ...

[@Brianna17]

Define the phases and purposes of chemotherapy for ALL.
 
  What will be an ideal response?

Question 2

Summarize and explain why patients develop the clinical signs and symptoms oberserved in patients with ALL.
 
  What will be an ideal response?

[nathang24]

Answer to Question 1

Answer: Chemotherapy for ALL is divided into several phases:
 Induction therapy phase: Reduce the disease to complete remission (i.e., eradicating the leukemic blast population).
 CNS prophylactic phase: Prevent CNS leukemia in young children. The two potential modes of treatment in the CNS prophylactic phase are cranium irradiation and/or intrathecal chemotherapy.
 Maintenance chemotherapy (cytoreductive therapy or remission consolidation therapy): Eradicate any remaining leukemic cells.

Answer to Question 2

Answer: The excessive proliferation of abnormal blasts that are present causes a crowding-out effect of normal hematopoietic cells. This leads to the following: frequent infections (because of low WBCs produced), fatigue, pallor, shortness of breath (from decreased RBCs produced), and bleeding and bruising symptoms (caused by decreased platelets produced).

[@Brianna17]

TYSM

[raenoj]

Gracias!