The strength and type of charge on a hemoglobin molecule enables the separation of hemoglobin variants by electrophoresis. What other significant factor controls this separation?
a. Solubility of the molecule
b. pH of the medium
c. Heat precipitation
d. Elevation of hemoglobin concentration
Question 2
A 2-year-old black male was being evaluated at County Clinic for swollen hands and feet that were extremely painful. Upon physical examination, the child was found to have a fever and hepatosplenomegaly and was physically small for his age.
The child was of Jamaican descent.
Patient history revealed that the child's birth weight was normal, but since then, he had been consistently underweight and undersized for his age group. Family history was not readily available. The physician had the child admitted to the hospital for workup and ordered the following CBC.
TEST RESULTS
WBC 16.6 x 109/L
RBC 2.53 x 1012/L
HGB 7.5 gm/dL
HCT 21.4
MCV 84.6 fl
MCH 18.9 pg
MCHC 35.0 g/dL
RDW 18.9
PLT 511 x 109/L
Differential:
Polys 84
Stabs (bands?) 10
Stab not commonly used
Lymphs 5
Eos 1
NRBCs 12
This patient presented with swollen hands and feet. This patient suffering from what kind of crisis?
a. Vaso-occlusive
b. Oxidative
c. Transfusion reaction
d. Anaphylactic reaction
Strength of Knee Joint
Human hemoglobin variants
Carrie Mae Weems, A Negroid Type, from the series From Here I Saw What Happened and I Cried.
Antidiabetic Drugs for Type 2 Diabetes
Combined effects of CO2 and BPG on oxygen binding by hemoglobin
Structure of a complex of a type II DNA methylase with DNA