This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Explain how hematopoiesis uses autocrine, paracrine, and juxtacrine signaling. Choose one and ... (Read 70 times)

biggirl4568

  • Hero Member
  • *****
  • Posts: 551
on: Jun 25, 2018
Explain how hematopoiesis uses autocrine, paracrine, and juxtacrine signaling. Choose one and provide an example of signaling through that pathway.
 
  What will be an ideal response?

Question 2

Explain the JAK-STAT signaling pathway, and describe how it can contribute to disease.
 
  What will be an ideal response?


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

perkiness

  • Sr. Member
  • ****
  • Posts: 348
Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer: Autocrine signaling: produced by and act on the same cell. Example: Rarely seen; T-cells and IL-2.
Paracrine signaling: produced by and act on adjacent cells. Example: progenitors and precursors adjacent to the BM stroma.
Juxtacrine signaling: The cytokine remains membrane-bound, which requires interaction between membrane and membrane receptors to achieve the desired effect. Example: stem cells and SCF or FL.

Answer to Question 2

Answer: JAK: Janus family PTKs (protein tyrosine kinases) interact with the STAT transcription factors (signal transducers and activators of transcription). Once STAT proteins are phosphorylated by activated JAK kinases, they dimerize, translocate to the nucleus, bind to cytokine-specific DNA sequences, and activate (or inhibit) specific gene expression. Abnormalities in this pathway have been shown to cause polycythemia vera and other myeloproliferative disorders.


biggirl4568

  • Member
  • Posts: 551
Reply 2 on: Jun 25, 2018
Wow, this really help

Laurenleakan

  • Member
  • Posts: 309
Reply 3 on: Yesterday
:D TYSM

« previous next »
 

Did you know?

More than nineteen million Americans carry the factor V gene that causes blood clots, pulmonary embolism, and heart disease.

Did you know?

The liver is the only organ that has the ability to regenerate itself after certain types of damage. As much as 25% of the liver can be removed, and it will still regenerate back to its original shape and size. However, the liver cannot regenerate after severe damage caused by alcohol.

Did you know?

The lipid bilayer is made of phospholipids. They are arranged in a double layer because one of their ends is attracted to water while the other is repelled by water.

Did you know?

Critical care patients are twice as likely to receive the wrong medication. Of these errors, 20% are life-threatening, and 42% require additional life-sustaining treatments.

Did you know?

Nearly all drugs pass into human breast milk. How often a drug is taken influences the amount of drug that will pass into the milk. Medications taken 30 to 60 minutes before breastfeeding are likely to be at peak blood levels when the baby is nursing.

cell signaling cytoplasmic response cell signaling cytoplasmic response
Signaling pathways involving the insulin receptor Signaling pathways involving the insulin receptor
A representation of the ethylene-signaling pathway A representation of the ethylene-signaling pathway
E9-23 Prepare income statements Explain the difference in operating income E9-23 Prepare income statements Explain the difference in operating income
Explain the assumptions that must be satisfied in order to validly use the one-way ANOVA ... Explain the assumptions that must be satisfied in order to validly use the one-way ANOVA ...
Components of the Notch signaling pathway in Drosophila Components of the Notch signaling pathway in Drosophila
Video: Dietary Cholesterol & LDL

For a complete list of videos, visit our video library