Answer to Question 1
ANS: A
In multiple sclerosis, visual disturbances may be the initial presenting symptom, indicating a plaque on the optic nerve. Associated visual disturbances include diplopia, blurred vision, tunnel vision, scotoma, or amaurosis. The visual changes are usually monocular. The patient may complain of intermittent weakness, parasthesias, or numbness of the face or extremities that occurs intermittently and that may resolve for weeks to months. Patients may report episodes of falling or stumbling with gait ataxia. Hyperreflexia may be noted, particularly in the lower extremities. Other symptoms include bladder incontinence or retention. Spastic bladder may also occur. In later stages, mental status changes may be noted. Initial symptoms are typically intermittent, and the disease may go undiagnosed for months or years.
Answer to Question 2
ANS: D
The history should include the type of weakness, whether it is proximal weakness, which might alert you to thyroid disease, malignancy, or adrenal dysfunction, or distal weakness, which would raise an index of suspicion for a neurological cause especially if it was accompanied by paresthesias. Ask the patient when and with what types of activities the weakness is most prominent and how much it interferes with activities of daily living. Inquire about changes in speech patterns or slurring that might indicate a neurological cause. Ask whether there are any cognitive or personality changes, which are often seen with adrenal dysfunction. The review of systems should include headache, cold or heat intolerance, change in appetite, weight gain or loss, nausea, vomiting or diarrhea, changes in balance or gait, numbness or paresthesia, diplopia or other vision changes, and difficulty with speech or swallowing.