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Medication errors are more common among seriously ill patients than with those with minor conditions.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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Asthma is the most common chronic childhood disease in the world. Most children who develop asthma have symptoms before they are 5 years old.
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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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In 1864, the first barbiturate (barbituric acid) was synthesized.