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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
Blood in the urine can be a sign of a kidney stone, glomerulonephritis, or other kidney problems.
The Romans did not use numerals to indicate fractions but instead used words to indicate parts of a whole.
Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.