Author Question: Through genetic testing a client is found to have a germline mutation of a specific gene. What ... (Read 147 times)

chandani · **on:** Jun 27, 2018

Through genetic testing a client is found to have a germline mutation of a specific gene. What information about this finding should be reviewed with the client?

1. No children will have the mutation.
2. All future children will have the mutation.
3. Only male children will have the mutation.
4. Only female children will have the mutation.

Question 2

After genetic testing, a client is suspected of having mitochondrial gene alteration. When reviewing the test result with the client, which body systems are noted as being affected by this alteration? Select all that apply.

1. Brain
2. Renal
3. Cardiac
4. Genitourinary
5. Musculoskeletal

matt · **Reply #1 on:** Jun 27, 2018

Answer to Question 1

2
Explanation:
1. Somatic mutations are not passed from one generation to another.
2. Hereditary mutations are passed to offspring from one or both parents and are also known as germline mutations because the mutation exists in the reproductive cells or gametes. The DNA in every cell of that offspring will have the mutation, which can then be transmitted to following generations.
3. This mutation exists in the reproductive cells and will affect both genders.
4. This mutation exists in the reproductive cells and will affect both genders.

Answer to Question 2

1, 3, 5
Explanation:
1. Clinical manifestations occurring as a result of mitochondrial gene alterations primarily affect high-energy tissues such as the brain.
2. Clinical manifestations occurring as a result of mitochondrial gene alterations primarily affect high-energy tissues. The renal system is not identified as being affected.
3. Clinical manifestations occurring as a result of mitochondrial gene alterations primarily affect high-energy tissues such as cardiac muscle.
4. Clinical manifestations occurring as a result of mitochondrial gene alterations primarily affect high-energy tissues. The genitourinary system is not identified as being affected.
5. Clinical manifestations occurring as a result of mitochondrial gene alterations primarily affect high-energy tissues such as skeletal muscle.