What is the earliest recognizable clinical manifestation(s) of ...

[neverstopbelieb]

What is the earliest recognizable clinical manifestation(s) of cystic fibrosis (CF)?
 
  a. Meconium ileus
  b. History of poor intestinal absorption
  c. Foul-smelling, frothy, greasy stools
  d. Recurrent pneumonia and lung infections

Question 2

Cystic fibrosis (CF) may affect single or multiple systems of the body. What is the primary factor responsible for possible multiple clinical manifestations in CF?
 
  a. Hyperactivity of sweat glands
  b. Hypoactivity of autonomic nervous system
  c. Atrophic changes in mucosal wall of intestines
  d. Mechanical obstruction caused by increased viscosity of mucous gland secretions

[flexer1n1]

Answer to Question 1

ANS: A
The earliest clinical manifestation of CF is a meconium ileus, which is found in about 10 of children with CF. Clinical manifestations include abdominal distention, vomiting, failure to pass stools, and rapid development of dehydration. History of malabsorption is a later sign that manifests as failure to thrive. Foul-smelling stools and recurrent respiratory infections are later manifestations of CF.

Answer to Question 2

ANS: D
The mucous glands produce a thick mucoprotein that accumulates and results in dilation. Small passages in organs such as the pancreas and bronchioles become obstructed as secretions form concretions in the glands and ducts. The exocrine glands, not sweat glands, are dysfunctional. Although abnormalities in the autonomic nervous system are present, it is not hypoactive. Intestinal involvement in CF results from the thick intestinal secretions, which can lead to blockage and rectal prolapse.

[neverstopbelieb]

TYSM

[xthemafja]

Thanks for the timely response, appreciate it