Author Question: A child, age 10 years, has a neuroblastoma and is in the hospital for additional chemotherapy ... (Read 32 times)

asan beg · **on:** Jun 28, 2018

A child, age 10 years, has a neuroblastoma and is in the hospital for additional chemotherapy treatments. What laboratory values are most likely this child's

a. White blood cell count, 17,000/mm3; hemoglobin, 15 g/dl
b. White blood cell count, 3,000/mm3; hemoglobin, 11.5 g/dl
c. Platelets, 450,000/mm3; hemoglobin, 12 g/dl
d. White blood cell count, 10,000/mm3; platelets, 175,000/mm3

Question 2

What specific gravity of the urine is desired so that hemorrhagic cystitis is prevented?

a. 1.035
b. 1.030
c. 1.025
d. 1.005

Athena23 · **Reply #1 on:** Jun 28, 2018

Answer to Question 1

ANS: B
Chemotherapy is the mainstay of therapy for extensive local or disseminated neuroblastoma. The drugs of choice are vincristine, doxorubicin, cyclophosphamide, cisplatin, etoposide, ifosfamide, and carboplatin. These cause immunosuppression, so the laboratory values will indicate a low white blood cell count and hemoglobin.

Answer to Question 2

ANS: D
Sterile hemorrhagic cystitis is a side effect of chemical irritation to the bladder from chemotherapy or radiotherapy. It can be prevented by a liberal oral or parenteral fluid intake (at least one and a half times the recommended daily fluid requirement). The urine should be dilute so 1.005 is the expected specific gravity.