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Tobacco depletes the body of vitamins A, C, and E, which can result in any of the following: dry hair, dry skin, dry eyes, poor growth, night blindness, abscesses, insomnia, fatigue, reproductive system problems, sinusitis, pneumonia, frequent respiratory problems, skin disorders, weight loss, rickets, osteomalacia, nervousness, muscle spasms, leg cramps, extremity numbness, bone malformations, decayed teeth, difficulty in walking, irritability, restlessness, profuse sweating, increased uric acid (gout), joint damage, damaged red blood cells, destruction of nerves, infertility, miscarriage, and many types of cancer.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
The FDA recognizes 118 routes of administration.
In 1844, Charles Goodyear obtained the first patent for a rubber condom.
The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.