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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Addicts to opiates often avoid treatment because they are afraid of withdrawal. Though unpleasant, with proper management, withdrawal is rarely fatal and passes relatively quickly.
There are more sensory neurons in the tongue than in any other part of the body.
Medication errors are three times higher among children and infants than with adults.
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.

