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In 1864, the first barbiturate (barbituric acid) was synthesized.
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ACTH levels are normally highest in the early morning (between 6 and 8 A.M.) and lowest in the evening (between 6 and 11 P.M.). Therefore, a doctor who suspects abnormal levels looks for low ACTH in the morning and high ACTH in the evening.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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The ratio of hydrogen atoms to oxygen in water (H2O) is 2:1.
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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.