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It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.
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Cyanide works by making the human body unable to use oxygen.
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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Patients who have been on total parenteral nutrition for more than a few days may need to have foods gradually reintroduced to give the digestive tract time to start working again.