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The familiar sounds of your heart are made by the heart's valves as they open and close.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Coca-Cola originally used coca leaves and caffeine from the African kola nut. It was advertised as a therapeutic agent and "pickerupper." Eventually, its formulation was changed, and the coca leaves were removed because of the effects of regulation on cocaine-related products.
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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.