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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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In the United States, there is a birth every 8 seconds, according to the U.S. Census Bureau's Population Clock.