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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
In most climates, 8 to 10 glasses of water per day is recommended for adults. The best indicator for adequate fluid intake is frequent, clear urination.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.
In the United States, an estimated 50 million unnecessary antibiotics are prescribed for viral respiratory infections.