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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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The Romans did not use numerals to indicate fractions but instead used words to indicate parts of a whole.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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Medication errors are three times higher among children and infants than with adults.