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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
The average person is easily confused by the terms pharmaceutics and pharmacology, thinking they are one and the same. Whereas pharmaceutics is the science of preparing and dispensing drugs (otherwise known as the science of pharmacy), pharmacology is the study of medications.
Although the Roman numeral for the number 4 has always been taught to have been "IV," according to historians, the ancient Romans probably used "IIII" most of the time. This is partially backed up by the fact that early grandfather clocks displayed IIII for the number 4 instead of IV. Early clockmakers apparently thought that the IIII balanced out the VIII (used for the number 8) on the clock face and that it just looked better.
Your heart beats over 36 million times a year.
Barbituric acid, the base material of barbiturates, was first synthesized in 1863 by Adolph von Bayer. His company later went on to synthesize aspirin for the first time, and Bayer aspirin is still a popular brand today.
![In the summer of 1793, a yellow fever epidemic struck Philadelphia, killing nearly 4,000. Tens of th](https://biology-forums.com/gallery/47/medium_374628_16_08_15_9_52_07_222511109.jpeg)
![On March 25, 1911, as scores of young factory girls leaped to their deaths from the eighth, ninth, a](https://biology-forums.com/gallery/47/medium_376716_26_08_15_11_19_27_22455374.jpeg)