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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
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Approximately 500,000 babies are born each year in the United States to teenage mothers.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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On average, the stomach produces 2 L of hydrochloric acid per day.