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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Excessive alcohol use costs the country approximately $235 billion every year.