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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.
Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
In the United States, an estimated 50 million unnecessary antibiotics are prescribed for viral respiratory infections.
More than 4.4billion prescriptions were dispensed within the United States in 2016.

