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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
The modern decimal position system was the invention of the Hindus (around 800 AD), involving the placing of numerals to indicate their value (units, tens, hundreds, and so on).
As the western states of America were settled, pioneers often had to drink rancid water from ponds and other sources. This often resulted in chronic diarrhea, causing many cases of dehydration and death that could have been avoided if clean water had been available.
Walt Disney helped combat malaria by making an animated film in 1943 called The Winged Scourge. This short film starred the seven dwarfs and taught children that mosquitos transmit malaria, which is a very bad disease. It advocated the killing of mosquitos to stop the disease.
The FDA recognizes 118 routes of administration.
![Scoop from (A) shoulders to (B) heels. Hold feet in one hand; with other hand use the palm to apply ...](https://biology-forums.com/gallery/33/medium_380798_23_08_17_7_43_57_33349268.jpeg)
![Apply lotion to the foot, lower leg, and thigh if accessible. Apply strokes from distal to proximal.](https://biology-forums.com/gallery/33/medium_380798_23_08_17_7_43_58_33356432.jpeg)