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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.
In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
Blood in the urine can be a sign of a kidney stone, glomerulonephritis, or other kidney problems.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.

