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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
More than 30% of American adults, and about 12% of children utilize health care approaches that were developed outside of conventional medicine.
Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
Cancer has been around as long as humankind, but only in the second half of the twentieth century did the number of cancer cases explode.
Elderly adults are at greatest risk of stroke and myocardial infarction and have the most to gain from prophylaxis. Patients ages 60 to 80 years with blood pressures above 160/90 mm Hg should benefit from antihypertensive treatment.