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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Signs and symptoms of a drug overdose include losing consciousness, fever or sweating, breathing problems, abnormal pulse, and changes in skin color.