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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.
On average, the stomach produces 2 L of hydrochloric acid per day.
Critical care patients are twice as likely to receive the wrong medication. Of these errors, 20% are life-threatening, and 42% require additional life-sustaining treatments.
There are approximately 3 million unintended pregnancies in the United States each year.