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Blood in the urine can be a sign of a kidney stone, glomerulonephritis, or other kidney problems.
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Thyroid conditions may make getting pregnant impossible.
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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.