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It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
Blood in the urine can be a sign of a kidney stone, glomerulonephritis, or other kidney problems.
Human kidneys will clean about 1 million gallons of blood in an average lifetime.