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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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This year, an estimated 1.4 million Americans will have a new or recurrent heart attack.
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The people with the highest levels of LDL are Mexican American males and non-Hispanic black females.
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Drug-induced pharmacodynamic effects manifested in older adults include drug-induced renal toxicity, which can be a major factor when these adults are experiencing other kidney problems.