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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
The ratio of hydrogen atoms to oxygen in water (H2O) is 2:1.
Anesthesia awareness is a potentially disturbing adverse effect wherein patients who have been paralyzed with muscle relaxants may awaken. They may be aware of their surroundings but unable to communicate or move. Neurologic monitoring equipment that helps to more closely check the patient's anesthesia stages is now available to avoid the occurrence of anesthesia awareness.
The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.